Todo sobre mi madre: A single mother in Madrid sees her only son die on his 17th birthday as he runs to seek an actresss autograph. She goes to Barcelona to find the lads father, a transvestite named Lola who does not know he has a child. First she finds her friend, Agrado, a wild yet caring transvestite; through him she meets Rosa, a young nun bound for El Salvador, but instead finds out she is pregnant by Lola. Manuela becomes the personal assistant of Huma Rojo, the actress her son admired, by helping Huma manage Nina, the co-star and Humas lover. However, Agrado soon takes over when Manuela must care for Hermana Rosas risky pregnancy. With echos of Lorca, All About Eve, and Streetcar Named Desire, the mothers (and fathers and actors) live out grief, love, and friendship.